Ontology highlight
ABSTRACT:
SUBMITTER: Gruber AR
PROVIDER: S-EPMC4282565 | biostudies-literature | 2014 Mar-Apr
REPOSITORIES: biostudies-literature
Gruber Andreas R AR Martin Georges G Keller Walter W Zavolan Mihaela M
Wiley interdisciplinary reviews. RNA 20131114 2
Expression of mature messenger RNAs (mRNAs) requires appropriate transcription initiation and termination, as well as pre-mRNA processing by capping, splicing, cleavage, and polyadenylation. A core 3'-end processing complex carries out the cleavage and polyadenylation reactions, but many proteins have been implicated in the selection of polyadenylation sites among the multiple alternatives that eukaryotic genes typically have. In recent years, high-throughput approaches to map both the 3'-end pr ...[more]