Ontology highlight
ABSTRACT:
SUBMITTER: Holmes ML
PROVIDER: S-EPMC4282578 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Holmes Melissa L ML Huntington Nicholas D ND Thong Rebecca P L RP Brady Jason J Hayakawa Yoshihiro Y Andoniou Christopher E CE Fleming Peter P Shi Wei W Smyth Gordon K GK Degli-Esposti Mariapia A MA Belz Gabrielle T GT Kallies Axel A Carotta Sebastian S Smyth Mark J MJ Nutt Stephen L SL
The EMBO journal 20141015 22
Natural killer (NK) cells are an innate lymphoid cell lineage characterized by their capacity to provide rapid effector functions, including cytokine production and cytotoxicity. Here, we identify the Ikaros family member, Aiolos, as a regulator of NK-cell maturation. Aiolos expression is initiated at the point of lineage commitment and maintained throughout NK-cell ontogeny. Analysis of cell surface markers representative of distinct stages of peripheral NK-cell maturation revealed that Aiolos ...[more]