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Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.

ABSTRACT: Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of ?-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

SUBMITTER: Sreenilayam G 

PROVIDER: S-EPMC4282819 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.

Sreenilayam Gopeekrishnan G   Fasan Rudi R  

Chemical communications (Cambridge, England) 20150101 8

Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope. ...[more]

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