Ontology highlight
ABSTRACT:
SUBMITTER: Cilfone NA
PROVIDER: S-EPMC4283220 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cilfone Nicholas A NA Ford Christopher B CB Marino Simeone S Mattila Joshua T JT Gideon Hannah P HP Flynn JoAnne L JL Kirschner Denise E DE Linderman Jennifer J JJ
Journal of immunology (Baltimore, Md. : 1950) 20141215 2
Although almost a third of the world's population is infected with the bacterial pathogen Mycobacterium tuberculosis, our understanding of the functions of many immune factors involved in fighting infection is limited. Determining the role of the immunosuppressive cytokine IL-10 at the level of the granuloma has proven difficult because of lesional heterogeneity and the limitations of animal models. In this study, we take an in silico approach and, through a series of virtual experiments, we pre ...[more]