Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression.
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ABSTRACT:
SUBMITTER: Blose KJ
PROVIDER: S-EPMC4283481 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression.
Blose Kory J KJ Ennis Terri L TL Arif Batool B Weinbaum Justin S JS Curci John A JA Vorp David A DA
Regenerative medicine 20140101 6
<h4>Aim</h4>Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA).<h4>Materials & methods</h4>AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a delivery device consisting of a subcutaneous port, tubing and porous scaffold was implanted. Five days after elastase perfusion, 100,000 ADMSCs were delivered through t ...[more]
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