Ontology highlight
ABSTRACT:
SUBMITTER: Ross KA
PROVIDER: S-EPMC4284014 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ross Kathleen A KA Loyd Hyelee H Wu Wuwei W Huntimer Lucas L Ahmed Shaheen S Sambol Anthony A Broderick Scott S Flickinger Zachary Z Rajan Krishna K Bronich Tatiana T Mallapragada Surya S Wannemuehler Michael J MJ Carpenter Susan S Narasimhan Balaji B
International journal of nanomedicine 20141230
H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhydride nanoparticles encapsulating subunit proteins have been shown to enhance humoral and cell-mediated immunity and provide protection upon lethal challenge. In this work, a recombinant H5 hemagglutinin trimer (H5₃) was produced and encapsul ...[more]