Ontology highlight
ABSTRACT:
SUBMITTER: Puskarjov M
PROVIDER: S-EPMC4284054 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Epilepsia 20140506 6
Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults. The paucity of evidence-based treatment guidelines, coupled with a rudimentary understanding of disease pathogenesis, has made the current treatment of neonatal seizures empiric and often ineffective, highlighting the need for novel therapies. Key developmental differences in γ-aminobutyric acid (GABA)ergic neurotrans ...[more]