Ontology highlight
ABSTRACT:
SUBMITTER: Sharma VK
PROVIDER: S-EPMC4284567 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Sharma Vikas K VK Patapoff Thomas W TW Kabakoff Bruce B Pai Satyan S Hilario Eric E Zhang Boyan B Li Charlene C Borisov Oleg O Kelley Robert F RF Chorny Ilya I Zhou Joe Z JZ Dill Ken A KA Swartz Trevor E TE
Proceedings of the National Academy of Sciences of the United States of America 20141215 52
For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant correlations with simple physical properties obtainable from antibody sequences and by molecular dynamics simulations of individual antibody molecules. mAbs viscosities increase strongly with hydrophobicity a ...[more]