Ontology highlight
ABSTRACT:
SUBMITTER: Waris S
PROVIDER: S-EPMC4284772 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20141216 12
Stress granule (SG) formation is a primary mechanism through which gene expression is rapidly modulated when the eukaryotic cell undergoes cellular stresses (including heat, oxidative, viral infection, starvation). In particular, the sequestration of specifically targeted translationally stalled mRNAs into SGs limits the expression of a subset of genes, but allows the expression of heatshock proteins that have a protective effect in the cell. The importance of SGs is seen in several disease stat ...[more]