Ontology highlight
ABSTRACT:
SUBMITTER: Podvinec M
PROVIDER: S-EPMC428484 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Podvinec Michael M Handschin Christoph C Looser Renate R Meyer Urs A UA
Proceedings of the National Academy of Sciences of the United States of America 20040603 24
Heme is an essential component of numerous hemoproteins with functions including oxygen transport, energy metabolism, and drug biotransformation. In nonerythropoietic cells, 5-aminolevulinate synthase (ALAS1) is the rate-limiting enzyme in heme biosynthesis. Upon exposure to drugs that induce cytochromes P450 and other drug-metabolizing enzymes, ALAS1 is transcriptionally up-regulated, increasing the rate of heme biosynthesis to provide heme for cytochrome P450 hemoproteins. We used a combined i ...[more]