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Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.


ABSTRACT: An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.

SUBMITTER: Dandapani S 

PROVIDER: S-EPMC4284946 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Dandapani Sivaraman S   Lowe Jason T JT   Comer Eamon E   Marcaurelle Lisa A LA  

The Journal of organic chemistry 20110829 19


An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained. ...[more]

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