Ontology highlight
ABSTRACT:
SUBMITTER: Moore AS
PROVIDER: S-EPMC4285339 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Moore Andrew S AS Alonzo Todd A TA Gerbing Robert B RB Lange Beverly J BJ Heerema Nyla A NA Franklin Janet J Raimondi Susana C SC Hirsch Betsy A BA Gamis Alan S AS Meshinchi Soheil S
Pediatric blood & cancer 20131011 4
<h4>Background</h4>The inhibitor-of-apoptosis protein survivin, encoded by BIRC5, regulates apoptosis, cell division and proliferation. Several survivin splice variants have been described however, the prognostic significance of their expression has not been well defined in pediatric acute myeloid leukemia (AML).<h4>Procedure</h4>Quantitative expression analyses of BIRC5 mRNA (n = 306) and survivin transcript splice variants (n = 90) were performed on diagnostic bone marrow samples from children ...[more]