Ontology highlight
ABSTRACT:
SUBMITTER: Atkins KM
PROVIDER: S-EPMC4285392 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Atkins Katelyn M KM Thomas Laura L LL Barroso-González Jonathan J Thomas Laurel L Auclair Sylvain S Yin Jun J Kang Hyeog H Chung Jay H JH Dikeakos Jimmy D JD Thomas Gary G
Cell reports 20140821 5
SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here, we demonstrate that the sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown cells failed to efficiently undergo p53-induced cell-cycle arrest in response to DNA damage. Accordingly, p53 acetylation was reduced both in PACS-2 knockdown cells and thymocytes from Pacs-2(-/-) mice, thereby blunting induction of the c ...[more]