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Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR.


ABSTRACT: V1aR has a well established role in the neural regulation of adult mammalian social behavior. The role of V1aR in developmentally emerging social behavior is less well understood. We mapped V1aR at post-natal day 8 (P8) and demonstrate developmentally-specific expression in the neocortex and hippocampus. We tested the ability of male and female C57BL/6J mice to show orienting bias to a familiar odor at this age. We demonstrate that females, but not males, show an orienting bias for odors previously paired with the mother, which is eliminated by V1aR signaling.

SUBMITTER: Hammock EA 

PROVIDER: S-EPMC4285782 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR.

Hammock Elizabeth A D EA   Law Caitlin S CS   Levitt Pat P  

Hormones and behavior 20121221 2


V1aR has a well established role in the neural regulation of adult mammalian social behavior. The role of V1aR in developmentally emerging social behavior is less well understood. We mapped V1aR at post-natal day 8 (P8) and demonstrate developmentally-specific expression in the neocortex and hippocampus. We tested the ability of male and female C57BL/6J mice to show orienting bias to a familiar odor at this age. We demonstrate that females, but not males, show an orienting bias for odors previou  ...[more]

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