Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann B
PROVIDER: S-EPMC4285808 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
International journal of clinical pharmacology and therapeutics 20141201 12
<h4>Objective</h4>To determine the relative bioavailability of ethinyl estradiol (EE) and gestodene (GSD) after application of a novel transdermal contraceptive patch vs. a standard combined oral contraceptive (COC) pill (study 1), and to evaluate the pharmacokinetics (PK) of EE after application of the EE/GSD patch compared with an EE/norelgestromin (NGMN) patch (study 2).<h4>Materials</h4>Participants were healthy, nonobese women aged 18 - 45 years (study 1) or 18 - 35 years (study 2). Composi ...[more]