A bifurcated proteoglycan binding small molecule carrier for siRNA delivery.
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ABSTRACT:
SUBMITTER: Gooding M
PROVIDER: S-EPMC4286013 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
A bifurcated proteoglycan binding small molecule carrier for siRNA delivery.
Gooding Matt M Adigbli Derick D Edith Chan A W AW Melander Roberta J RJ MacRobert Alexander J AJ Selwood David L DL
Chemical biology & drug design 20140513 1
A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC. ...[more]
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