Ontology highlight
ABSTRACT:
SUBMITTER: Bestembayeva A
PROVIDER: S-EPMC4286247 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bestembayeva Aizhan A Kramer Armin A Labokha Aksana A AA Osmanović Dino D Liashkovich Ivan I Orlova Elena V EV Ford Ian J IJ Charras Guillaume G Fassati Ariberto A Hoogenboom Bart W BW
Nature nanotechnology 20141124 1
The nuclear pore complex (NPC) is the gate for transport between the cell nucleus and the cytoplasm. Small molecules cross the NPC by passive diffusion, but molecules larger than ∼5 nm must bind to nuclear transport receptors to overcome a selective barrier within the NPC. Although the structure and shape of the cytoplasmic ring of the NPC are relatively well characterized, the selective barrier is situated deep within the central channel of the NPC and depends critically on unstructured nuclear ...[more]