From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution's experience.
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ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC4286371 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution's experience.
Zhao Weiqiang W Damodaran Senthilkumar S Villalona-Calero Miguel A MA
Lung cancer management 20140801 3
Molecular selection has led to the successful use of novel tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancers (NSCLCs). For instance, mutations in <i>EGFR</i> and translocations and fusions in <i>ALK</i> render tumor cells sensitive to some TKIs, leading to substantial clinical benefits. Molecular testing such as DNA sequencing or fragment analysis following PCR, and evaluation of copy number and gene positioning by FISH, have been developed and used clinically to identify mutation ...[more]
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