LASP1 is a HIF1? target gene critical for metastasis of pancreatic cancer.
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ABSTRACT:
SUBMITTER: Zhao T
PROVIDER: S-EPMC4286473 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.
Zhao Tiansuo T Ren He H Li Jing J Chen Jing J Zhang Huan H Xin Wen W Sun Yan Y Sun Lei L Yang Yongwei Y Sun Junwei J Wang Xiuchao X Gao Song S Huang Chongbiao C Zhang Huafeng H Yang Shengyu S Hao Jihui J
Cancer research 20141110 1
LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells. Here, we report that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDA ...[more]
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