Ontology highlight
ABSTRACT:
SUBMITTER: Marchetti F
PROVIDER: S-EPMC4286742 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Marchetti Francesco F Bishop Jack J Gingerich John J Wyrobek Andrew J AJ
Scientific reports 20150108
De novo point mutations and chromosomal structural aberrations (CSA) detected in offspring of unaffected parents show a preferential paternal origin with higher risk for older fathers. Studies in rodents suggest that heritable mutations transmitted from the father can arise from either paternal or maternal misrepair of damaged paternal DNA, and that the entire spermatogenic cycle can be at risk after mutagenic exposure. Understanding the susceptibility and mechanisms of transmission of paternal ...[more]