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Fate-restricted neural progenitors in the mammalian cerebral cortex.

ABSTRACT: During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.

SUBMITTER: Franco SJ

PROVIDER: S-EPMC4287277 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Fate-restricted neural progenitors in the mammalian cerebral cortex.

Franco Santos J SJ Gil-Sanz Cristina C Martinez-Garay Isabel I Espinosa Ana A Harkins-Perry Sarah R SR Ramos Cynthia C Müller Ulrich U

Science (New York, N.Y.) 20120801 6095

During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potent ...[more]

PMID: 22879516

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