Ontology highlight
ABSTRACT:
SUBMITTER: Godfrey M
PROVIDER: S-EPMC4287440 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Godfrey Molly M Kuilman Thomas T Uhlmann Frank F
PLoS genetics 20150108 1
Substrate dephosphorylation by the cyclin-dependent kinase (Cdk)-opposing phosphatase, Cdc14, is vital for many events during budding yeast mitotic exit. Cdc14 is sequestered in the nucleolus through inhibitory binding to Net1, from which it is released in anaphase following Net1 phosphorylation. Initial Net1 phosphorylation depends on Cdk itself, in conjunction with proteins of the Cdc14 Early Anaphase Release (FEAR) network. Later on, the Mitotic Exit Network (MEN) signaling cascade maintains ...[more]