Ontology highlight
ABSTRACT:
SUBMITTER: Dai LL
PROVIDER: S-EPMC4287614 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Dai Li-Li LL Gao Jin-Xia JX Zou Cheng-Gang CG Ma Yi-Cheng YC Zhang Ke-Qin KQ
PLoS pathogens 20150108 1
The unfolded protein response (UPR), which is activated by perturbations of the endoplasmic reticulum homeostasis, has been shown to play an important role in innate immunity and inflammation. However, little is known about the molecular mechanisms underlying activation of the UPR during immune responses. Using small RNA deep sequencing and reverse genetic analysis, we show that the microRNA mir-233 is required for activation of the UPR in Caenorhabditis elegans exposed to Pseudomonas aeruginosa ...[more]