Unknown

Dataset Information

0

Association of interleukin 1 beta (IL-1?) polymorphism with mRNA expression and risk of non small cell lung cancer.

ABSTRACT: INTRODUCTION:Interleukin 1 beta (IL- 1?), a key proinflammatory cytokine encoded by the interleukin 1 beta gene, has been associated with chronic inflammation and plays an important role in lung inflammatory diseases including lung cancer. Elevated levels of Interleukin 1proteins, in particular interleukin 1 beta greatly enhance the intensity of the inflammatory response. AIM:To study the role of interleukin 1 beta-31C > T and -511 T > C polymorphism in the pathogenesis of non small cell lung cancer (NSCLC). MATERIALS AND METHODS:One hundred and ninety non small cell lung cancer patients and 200 healthy age, sex, smoking and dwelling matched controls were used for polymorphic analysis by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) followed by sequencing. Normal tissues of 48 histopathologically confirmed non small cell lung cancer patients were taken for mRNA expression analysis. Quantitation of interleukin 1 beta was carried out by quantitative real time PCR. RESULT:The T/T genotype of interleukin 1 beta-31 gene was significantly associated with increased risk of NSCLC [(P = 0.001, OR - 2.8 (95%CI 1.52-5.26)]. The interleukin 1 beta - 511 T > C does not show any difference between the NSCLC and control group (P = 0.3, OR - 0.72 (95%CI 0.41-1.28). Quantitative analysis of mRNA showed significant association with interleukin 1 beta T allele as compared to the interleukin 1 beta-31C allele (P = 0.006). CONCLUSION:We conclude that lung cancer risk genotype interleukin 1 beta-31TT results in increased expression of interleukin 1 beta mRNA in lung cancer patients. Our data suggest that this genotype (IL1? -31TT) in the interleukin 1 beta regulatory region provide a microenvironment with elevated inflammatory stimuli and thus increasing the risk for lung cancer.

SUBMITTER: Bhat IA 

PROVIDER: S-EPMC4287803 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Association of interleukin 1 beta (IL-1β) polymorphism with mRNA expression and risk of non small cell lung cancer.

Bhat Imtiyaz A IA   Naykoo Niyaz A NA   Qasim Iqbal I   Ganie Farooq A FA   Yousuf Qaiser Q   Bhat Bashir A BA   Rasool Roohi R   Aziz S A SA   Shah Zafar Amin ZA  

Meta gene 20140117

<h4>Introduction</h4>Interleukin 1 beta (IL- 1β), a key proinflammatory cytokine encoded by the interleukin 1 beta gene, has been associated with chronic inflammation and plays an important role in lung inflammatory diseases including lung cancer. Elevated levels of Interleukin 1proteins, in particular interleukin 1 beta greatly enhance the intensity of the inflammatory response.<h4>Aim</h4>To study the role of interleukin 1 beta-31C > T and -511 T > C polymorphism in the pathogenesis of non sma  ...[more]

Similar Datasets

Unknown Interleukin-1β (IL-1β) & IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) & their association with susceptibility to SLE.
| S-EPMC4989832 | biostudies-literature
Unknown L-arginine attenuates Interleukin-1β (IL-1β) induced Nuclear Factor Kappa-Beta (NF-κB) activation in Caco-2 cells.
| S-EPMC5363947 | biostudies-literature
Unknown Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence.
| S-EPMC9275897 | biostudies-literature
Unknown Association between interleukin-36γ and tumor progression in non-small cell lung cancer.
| S-EPMC7039103 | biostudies-literature
Unknown Association of NLRP1 Coding Polymorphism with Lung Function and Serum IL-1β Concentration in Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
| S-EPMC6826440 | biostudies-literature
Unknown Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer.
| S-EPMC6962381 | biostudies-literature
Unknown Interleukin 1α (IL-1α) Promotes Pathogenic Immature Myeloid Cells and IL-1β Favors Protective Mature Myeloid Cells During Acute Lung Infection.
| S-EPMC6692884 | biostudies-literature
Unknown Interleukin-27 rs153109 polymorphism and the risk of non-small-cell lung cancer in a Chinese population.
| S-EPMC4770075 | biostudies-literature
Unknown Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis.
| S-EPMC6451750 | biostudies-literature
Unknown Iron potentiates microglial interleukin-1β secretion induced by amyloid-β.
| S-EPMC7565447 | biostudies-literature