Unknown

Dataset Information

0

A genome-wide association study of marginal zone lymphoma shows association to the HLA region.


ABSTRACT: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

SUBMITTER: Vijai J 

PROVIDER: S-EPMC4287989 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4185120 | biostudies-literature
| S-EPMC1851160 | biostudies-literature
| S-EPMC3428941 | biostudies-literature
| PRJNA167668 | ENA
| phs000502.v1.p1 | EGA
| S-EPMC5016706 | biostudies-literature
2015-04-23 | PXD001124 | Pride
| S-EPMC6965379 | biostudies-literature
| S-EPMC3428949 | biostudies-literature
| S-EPMC8719063 | biostudies-literature