Ontology highlight
ABSTRACT:
SUBMITTER: Marsousi N
PROVIDER: S-EPMC4288002 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Marsousi N N Daali Y Y Rudaz S S Almond L L Humphries H H Desmeules J J Samer C F CF
CPT: pharmacometrics & systems pharmacology 20141217
Evaluation of a potential risk of metabolic drug-drug interactions (DDI) is of high importance in the clinical setting. In this study, a physiologically based pharmacokinetic (PBPK) model was developed for oxycodone and its two primary metabolites, oxymorphone and noroxycodone, in order to assess different DDI scenarios using published in vitro and in vivo data. Once developed and refined, the model was able to simulate pharmacokinetics of the three compounds and the DDI extent in case of coadmi ...[more]