Ontology highlight
ABSTRACT:
SUBMITTER: Taverniti V
PROVIDER: S-EPMC4288156 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Taverniti Valerio V Séraphin Bertrand B
Nucleic acids research 20141128 1
Eukaryotic 5' mRNA cap structures participate to the post-transcriptional control of gene expression before being released by the two main mRNA decay pathways. In the 3'-5' pathway, the exosome generates free cap dinucleotides (m7GpppN) or capped oligoribonucleotides that are hydrolyzed by the Scavenger Decapping Enzyme (DcpS) forming m7GMP. In the 5'-3' pathway, the decapping enzyme Dcp2 generates m7GDP. We investigated the fate of m7GDP and m7GpppN produced by RNA decay in extracts and cells. ...[more]