Ontology highlight
ABSTRACT:
SUBMITTER: Brechemier-Baey D
PROVIDER: S-EPMC4288165 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bréchemier-Baey Dominique D Domínguez-Ramírez Lenin L Oberto Jacques J Plumbridge Jacqueline J
Nucleic acids research 20141201 1
NagC and Mlc, paralogous members of the ROK family of proteins with almost identical helix-turn-helix DNA binding motifs, specifically regulate genes for transport and utilization of N-acetylglucosamine and glucose. We previously showed that two amino acids in a linker region outside the canonical helix-turn-helix motif are responsible for Mlc site specificity. In this work we identify four amino acids in the linker, which are required for recognition of NagC targets. These amino acids allow Mlc ...[more]