Consolidation in older adults depends upon competition between resting-state networks.

ABSTRACT: Memory encoding and retrieval problems are inherent to aging. To date, however, the effect of aging upon the neural correlates of forming memory traces remains poorly understood. Resting-state fMRI connectivity can be used to investigate initial consolidation. We compared within and between network connectivity differences between healthy young and older participants before encoding, after encoding and before retrieval by means of resting-state fMRI. Alterations over time in the between-network connectivity analyses correlated with retrieval performance, whereas within-network connectivity did not: a higher level of negative coupling or competition between the default mode and the executive networks during the after encoding condition was associated with increased retrieval performance in

SUBMITTER: Jacobs HI 

PROVIDER: S-EPMC4288239 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature