The mTOR signaling pathway as a treatment target for intracranial neoplasms.
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ABSTRACT:
SUBMITTER: Pachow D
PROVIDER: S-EPMC4288522 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
The mTOR signaling pathway as a treatment target for intracranial neoplasms.
Pachow Doreen D Wick Wolfgang W Gutmann David H DH Mawrin Christian C
Neuro-oncology 20140827 2
Inhibition of the mammalian target of rapamycin (mTOR) signaling pathway has become an attractive target for human cancer therapy. Hyperactivation of mTOR has been reported in both sporadic and syndromic (hereditary) brain tumors. In contrast to the large number of successful clinical trials employing mTOR inhibitors in different types of epithelial neoplasms, their use to treat intracranial neoplasms is more limited. In this review, we summarize the role of mTOR activation in brain tumor pathog ...[more]
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