Dataset Information

Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort.

ABSTRACT: Sleep breathing disorder (SBD) may be an important factor in age-related cognitive decline. In a cohort of healthy elderly subjects, we performed an 8-y longitudinal study to assess whether changes in cognitive function occur in untreated elderly patients with SBD and without dementia and the factors implicated in these changes.A population-based longitudinal study.Clinical research settings.A total of 559 participants of the PROOF study aged 67 y at the study entry and free from neurological disorders were examined.N/A.Abnormal breathing events were defined by an apnea-hypopnea index (AHI) > 15. The raw cognitive data and averaged Z-scores for the attentional, executive, and memory functions were collected at the baseline and follow-up. At baseline, AHI > 15 was found in 54% of subjects with 18% having an AHI > 30. At follow-up, the presence of abnormal breathing events was associated with a slight but significant decline in the attentional domain (P = 0.01), which was more evident in the subjects with an AHI > 30 (P = 0.004). No significant changes over time were observed in the executive and memory functions. Several indices of chronic hypoxemia, defined either as a cumulative peripheral oxygen saturation (SpO2) < 90% or a minimal SpO2, accounted for portions of the variance in the decline in attention. All observed effects were small, accounting for 4-7% of variance in multivariate models.In healthy elderly subjects, various components of sleep breathing disorder at baseline were associated with small changes in selected cognitive functions specific to the attention domain after controlling for multiple comorbidities, such as sleepiness, hypertension, diabetes, anxiety, and depression.ClinicalTrials.gov identifiers NCT 00759304 and NCT 00766584.

SUBMITTER: Martin MS

PROVIDER: S-EPMC4288598 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort.

Martin Magali Saint MS Sforza Emilia E Roche Frédéric F Barthélémy Jean Claude JC Thomas-Anterion Catherine C

Sleep 20150201 2

<h4>Study objectives</h4>Sleep breathing disorder (SBD) may be an important factor in age-related cognitive decline. In a cohort of healthy elderly subjects, we performed an 8-y longitudinal study to assess whether changes in cognitive function occur in untreated elderly patients with SBD and without dementia and the factors implicated in these changes.<h4>Design</h4>A population-based longitudinal study.<h4>Setting</h4>Clinical research settings.<h4>Participants</h4>A total of 559 participants ...[more]

PMID: 25325480

Similar Datasets

Project description:BackgroundPrevious studies show that the consumption of tea is associated with several beneficial outcomes for brain health, but there is little data among the elderly in China.ObjectiveThe objective was to explore the longitudinal relationship between tea consumption and the risk of cognitive decline.MethodsThe current data was obtained from the China Longitudinal Aging Study (CLAS), and a total of 3,246 residents aged 60 years and above were recruited in this study. Some of them (N = 111) underwent a standard T1-weighted magnetic resonance imaging (MRI), from which the volumes of the corpus callosum (CC) and hippocampus were calculated, and detailed tea consumption information was obtained through a standardized questionnaire at baseline. The cognitive diagnosis of each participant was made by attending psychiatrists at baseline and follow-up. Their overall cognitive function was assessed by the Montreal Cognitive Assessment (MoCA), while their associative learning ability was assessed by an associative learning test (ALT). Finally, 1,545 elderly with normal cognitive function completed the baseline and follow-up assessment and were included in the final study.ResultsAfter controlling gender, education, smoking, take exercise and hobbies, we found that the elderly with tea consumption habits had a lower incidence rate of cognitive decline (p = 0.002, OR = 0.604, 95%CI:0.437~0.836) and tea consumption was negatively correlated with the change scores of MoCA (r = -0.056, p = 0.029). What's more, the CC_posterior volume of tea drinkers was significantly smaller than that of non-tea drinkers, while the baseline ALT score of tea drinkers was significantly higher than that of non-tea drinkers. The results of correlation analysis showed that the CC_posterior volume was significantly correlated with ALT change score (r = -0.319, p = 0.010).ConclusionsThe habit of tea consumption is associated with less incidence of cognitive impairment among the Chinese elderly, and it may prevent a decline in memory and associative learning by affecting the volume of the posterior corpus callosum.

Dataset Information

Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort.

Publications

Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets