Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae.
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ABSTRACT:
SUBMITTER: Warner CJ
PROVIDER: S-EPMC4288701 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae.
Warner Christopher J A CJ Cheng Andrew T AT Yildiz Fitnat H FH Linington Roger G RG
Chemical communications (Cambridge, England) 20150101 7
Bacterial biofilms are estimated to be associated with over 65 percent of all nosocomial infections. However, no therapeutics have been approved by the FDA which directly mediate biofilm formation or persistence. Herein we report oxazine as a highly potent inhibitor, disperser and in the presence of the appropriate antibiotic eradicator of V. cholerae biofilms. ...[more]
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