Ontology highlight
ABSTRACT:
SUBMITTER: Dhungel N
PROVIDER: S-EPMC4289081 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Dhungel Nripesh N Eleuteri Simona S Li Ling-Bo LB Kramer Nicholas J NJ Chartron Justin W JW Spencer Brian B Kosberg Kori K Fields Jerel Adam JA Stafa Klodjan K Adame Anthony A Lashuel Hilal H Frydman Judith J Shen Kang K Masliah Eliezer E Gitler Aaron D AD
Neuron 20141218 1
Parkinson's disease (PD) is a common neurodegenerative disorder. Functional interactions between some PD genes, like PINK1 and parkin, have been identified, but whether other ones interact remains elusive. Here we report an unexpected genetic interaction between two PD genes, VPS35 and EIF4G1. We provide evidence that EIF4G1 upregulation causes defects associated with protein misfolding. Expression of a sortilin protein rescues these defects, downstream of VPS35, suggesting a potential role for ...[more]