OrthoClust: an orthology-based network framework for clustering data across multiple species.
Ontology highlight
ABSTRACT:
SUBMITTER: Yan KK
PROVIDER: S-EPMC4289247 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
OrthoClust: an orthology-based network framework for clustering data across multiple species.
Yan Koon-Kiu KK Wang Daifeng D Rozowsky Joel J Zheng Henry H Cheng Chao C Gerstein Mark M
Genome biology 20140828 8
Increasingly, high-dimensional genomics data are becoming available for many organisms.Here, we develop OrthoClust for simultaneously clustering data across multiple species. OrthoClust is a computational framework that integrates the co-association networks of individual species by utilizing the orthology relationships of genes between species. It outputs optimized modules that are fundamentally cross-species, which can either be conserved or species-specific. We demonstrate the application of ...[more]
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