Ontology highlight
ABSTRACT:
SUBMITTER: Stephan SB
PROVIDER: S-EPMC4289408 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Stephan Sirkka B SB Taber Alexandria M AM Jileaeva Ilona I Pegues Ericka P EP Sentman Charles L CL Stephan Matthias T MT
Nature biotechnology 20141215 1
Although adoptive T-cell therapy holds promise for the treatment of many cancers, its clinical utility has been limited by problems in delivering targeted lymphocytes to tumor sites, and the cells' inefficient expansion in the immunosuppressive tumor microenvironment. Here we describe a bioactive polymer implant capable of delivering, expanding and dispersing tumor-reactive T cells. The approach can be used to treat inoperable or incompletely removed tumors by situating implants near them or at ...[more]