Ontology highlight
ABSTRACT:
SUBMITTER: Renault TT
PROVIDER: S-EPMC4289414 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20141204 1
Proapoptotic BCL-2 proteins converge upon the outer mitochondrial membrane (OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Here we investigated the mechanistic relationship between mitochondrial shape and MOMP and provide evidence that BAX requires a distinct mitochondrial size to induce MOMP. We utilized the terminal unfolded protein response pathway to systematically define proapoptotic BCL-2 protein composition after stress and then directly interrogated t ...[more]