Ontology highlight
ABSTRACT:
SUBMITTER: Luche H
PROVIDER: S-EPMC4291128 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Luche Hervé H Ardouin Laurence L Teo Pearline P See Peter P Henri Sandrine S Merad Miriam M Ginhoux Florent F Malissen Bernard B
European journal of immunology 20110704 8
The dendritic cells (DCs) present in lymphoid and non-lymphoid organs are generated from progenitors with myeloid-restricted potential. However, in the thymus a major subset of DCs expressing CD8α and langerin (CD207) appears to stand apart from all other DCs in that it is thought to derive from progenitors with lymphoid potential. Using mice expressing a fluorescent reporter and a diphtheria toxin receptor under the control of the cd207 gene, we demonstrated that CD207(+) CD8α(+) thymic DCs do ...[more]