Ontology highlight
ABSTRACT:
SUBMITTER: Bell GP
PROVIDER: S-EPMC4291145 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bell Graham P GP Fletcher Georgina C GC Brain Ruth R Thompson Barry J BJ
Current biology : CB 20141204 1
The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia. In neuroblasts, Lgl relocalizes to the cytoplasm at mitosis, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to promote asymmetric cell division. Here we show that Lgl also relocalizes to the cytoplasm at mitosis in epithelial cells, which divide symmetrically. The Aurora A and B kinases directly phosphorylate Lgl ...[more]