Ontology highlight
ABSTRACT:
SUBMITTER: Romanov RA
PROVIDER: S-EPMC4291479 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Romanov Roman A RA Alpár Alán A Zhang Ming-Dong MD Zeisel Amit A Calas André A Landry Marc M Fuszard Matthew M Shirran Sally L SL Schnell Robert R Dobolyi Árpád Á Oláh Márk M Spence Lauren L Mulder Jan J Martens Henrik H Palkovits Miklós M Uhlen Mathias M Sitte Harald H HH Botting Catherine H CH Wagner Ludwig L Linnarsson Sten S Hökfelt Tomas T Harkany Tibor T
The EMBO journal 20141127 1
A hierarchical hormonal cascade along the hypothalamic-pituitary-adrenal axis orchestrates bodily responses to stress. Although corticotropin-releasing hormone (CRH), produced by parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) and released into the portal circulation at the median eminence, is known to prime downstream hormone release, the molecular mechanism regulating phasic CRH release remains poorly understood. Here, we find a cohort of parvocellular cells intersperse ...[more]