Ontology highlight
ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC4291542 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Kim Daniel H DH Marinov Georgi K GK Pepke Shirley S Singer Zakary S ZS He Peng P Williams Brian B Schroth Gary P GP Elowitz Michael B MB Wold Barbara J BJ
Cell stem cell 20150101 1
Cellular reprogramming highlights the epigenetic plasticity of the somatic cell state. Long noncoding RNAs (lncRNAs) have emerging roles in epigenetic regulation, but their potential functions in reprogramming cell fate have been largely unexplored. We used single-cell RNA sequencing to characterize the expression patterns of over 16,000 genes, including 437 lncRNAs, during defined stages of reprogramming to pluripotency. Self-organizing maps (SOMs) were used as an intuitive way to structure and ...[more]