Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation.
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ABSTRACT:
SUBMITTER: Jeon JS
PROVIDER: S-EPMC4291627 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation.
Jeon Jessie S JS Bersini Simone S Gilardi Mara M Dubini Gabriele G Charest Joseph L JL Moretti Matteo M Kamm Roger D RD
Proceedings of the National Academy of Sciences of the United States of America 20141218 1
A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells. Extravasation rates and microvasculature permeabilities ...[more]
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