Ontology highlight
ABSTRACT:
SUBMITTER: Rousseau A
PROVIDER: S-EPMC4292048 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rousseau Adrien A Wilhelm Léa P LP Tomasetto Catherine C Alpy Fabien F
Tissue barriers 20140808 4
Tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4), a protein localized in TJs in normal epithelial cells, is frequently overexpressed in carcinomas. We recently found that TRAF4 impedes TJ formation/stability and favors cell migration, 2 hallmarks of cancer progression. In addition TRAF4 contributes to the TGF-β-induced epithelial-mesenchymal transition (EMT), metastasis, and p53 destabilization. TRAF4 recruitment to TJs is a prerequisite for its biological function on TJ formatio ...[more]