CD137 stimulation enhances the vaccinal effect of anti-tumor antibodies.
Ontology highlight
ABSTRACT:
SUBMITTER: Houot R
PROVIDER: S-EPMC4292240 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
CD137 stimulation enhances the vaccinal effect of anti-tumor antibodies.
Oncoimmunology 20140703 7
Some evidence suggests that monoclonal antibodies (mAb) can induce an adaptive immune response against tumor cells ("vaccinal effect"). Recently, we have shown that an anti-CD137 mAb can enhance the "vaccinal effect" of an anti-tumor mAb (cetuximab), thereby transforming a passive, monoclonal, short-term immunotherapy into an active, polyclonal, long-lasting immune response. ...[more]
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