Overcoming immunosuppression to enhance a p53MVA vaccine.
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ABSTRACT:
SUBMITTER: Hardwick N
PROVIDER: S-EPMC4292557 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Overcoming immunosuppression to enhance a p53MVA vaccine.
Hardwick Nicola N Chung Vincent V Cristea Mihaela M Ellenhorn Joshua DI JD Diamond Don J DJ
Oncoimmunology 20141101 10
A Phase I trial of a p53-targeting modified vaccinia Ankara (p53MVA) vaccine in patients afflicted with refractory gastrointestinal cancers demonstrated enhanced T-cell recognition of p53 following vaccination. However, this effect was transient suggesting that p53MVA requires combination with immunomodulatory agents to deliver clinical benefit. Here, we outline our rationale for combining p53MVA with immunomodulatory chemotherapy in a forthcoming trial. ...[more]
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