Ontology highlight
ABSTRACT:
SUBMITTER: Michaud HA
PROVIDER: S-EPMC4292589 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Michaud Henri-Alexandre HA Eliaou Jean-François JF Lafont Virginie V Bonnefoy Nathalie N Gros Laurent L
Oncoimmunology 20141001 9
Tumor antigen (TA)-targeting monoclonal antibody (mAb)-based treatments are considered to be one of the most successful strategies in cancer therapy. Besides targeting TAs and inducing tumor cell death, such antibodies interact with immune cells through Fc-dependent mechanisms to induce adaptive memory immune responses. However, multiple inhibitory/immunosuppressive pathways can be induced by tumor cells to limit the establishment of an efficient antitumor response and consequently a sustained c ...[more]