Unknown

Dataset Information

0

Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.


ABSTRACT: BACKGROUND:We examined the effects of moderate prenatal alcohol exposure and/or prenatal stress exposure on (D1 R) binding in a non human primate model. The dopamine D1 R is involved in executive function, and it may play a role in cognitive behavioral deficits associated with prenatal alcohol and/or stress exposure. Little is known, however, about the effects of prenatal alcohol and/or stress exposure on the D1 R. We expected that prenatal insults would lead to alterations in D1 R binding in prefrontal cortex (PFC) and striatum in adulthood. METHODS:Rhesus macaque females were randomly assigned to moderate alcohol exposure and/or mild prenatal stress as well as a control condition during pregnancy. Thirty-eight offspring were raised identically and studied as adults by noninvasive in vivo neuroimaging using positron emission tomography with the D1 antagonist radiotracer [(11) C]SCH 23390. Radiotracer binding in PFC and striatum was evaluated by 2 (alcohol) × 2 (stress) × 2 (sex) analysis of variance. RESULTS:In PFC, a significant alcohol × sex interaction was observed with prenatal alcohol exposure leading to increased [(11) C]SCH 23390 binding in male monkeys. No main effect of prenatal alcohol or prenatal stress exposure was observed. CONCLUSIONS:These results suggest that prenatal alcohol exposure results in long-term increases in prefrontal dopamine D1 R binding in males. This may help explain gender differences in the prevalence of neurodevelopmental disorders consequent to prenatal alcohol exposure.

SUBMITTER: Converse AK 

PROVIDER: S-EPMC4293080 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.

Converse Alexander K AK   Moore Colleen F CF   Holden James E JE   Ahlers Elizabeth O EO   Moirano Jeffrey M JM   Larson Julie A JA   Resch Leslie M LM   DeJesus Onofre T OT   Barnhart Todd E TE   Nickles Robert J RJ   Murali Dhanabalan D   Christian Bradley T BT   Schneider Mary L ML  

Alcoholism, clinical and experimental research 20141201 12


<h4>Background</h4>We examined the effects of moderate prenatal alcohol exposure and/or prenatal stress exposure on (D1 R) binding in a non human primate model. The dopamine D1 R is involved in executive function, and it may play a role in cognitive behavioral deficits associated with prenatal alcohol and/or stress exposure. Little is known, however, about the effects of prenatal alcohol and/or stress exposure on the D1 R. We expected that prenatal insults would lead to alterations in D1 R bindi  ...[more]

Similar Datasets

| S-EPMC5111596 | biostudies-literature
| S-EPMC6980377 | biostudies-literature
| S-EPMC8591773 | biostudies-literature
| S-EPMC3932370 | biostudies-literature
| S-EPMC2872507 | biostudies-literature
| S-EPMC4269716 | biostudies-literature
| S-EPMC6861272 | biostudies-literature
| S-EPMC3951841 | biostudies-literature
| S-EPMC2875311 | biostudies-literature
| S-EPMC4259988 | biostudies-literature