Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC4293443 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Xu Dan D Wu Manhong M Nishimura Sachiko S Nishimura Toshihiko T Michie Sara A SA Zheng Ming M Yang Zicheng Z Yates Alexander John AJ Day Jeffrey S JS Hillgren Kathleen M KM Takeda Saori Takedai ST Guan Yuan Y Guo Yingying Y Peltz Gary G
The Journal of pharmacology and experimental therapeutics 20141125 2
Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) in humans is often not predicted by studies performed in animal species. For example, a drug (bosentan) used to treat pulmonary artery hypertension caused unexpected cholestatic liver toxicity in humans, which was not predicted by preclinical toxicology studies in multiple animal species. In this study, we demonstrate that NOG mice expressing a thymidine kinase transgene (TK-NOG) ...[more]