Ontology highlight
ABSTRACT:
SUBMITTER: Williams MJ
PROVIDER: S-EPMC4294236 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Williams Monique J MJ Shanley Crystal A CA Zilavy Andrew A Peixoto Blas B Manca Claudia C Kaplan Gilla G Orme Ian M IM Mizrahi Valerie V Kana Bavesh D BD
Infection and immunity 20141117 2
Mycobacterium tuberculosis is able to synthesize molybdopterin cofactor (MoCo), which is utilized by numerous enzymes that catalyze redox reactions in carbon, nitrogen, and sulfur metabolism. In bacteria, MoCo is further modified through the activity of a guanylyltransferase, MobA, which converts MoCo to bis-molybdopterin guanine dinucleotide (bis-MGD), a form of the cofactor that is required by the dimethylsulfoxide (DMSO) reductase family of enzymes, which includes the nitrate reductase NarGHI ...[more]