Ontology highlight
ABSTRACT:
SUBMITTER: Poli A
PROVIDER: S-EPMC4294327 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Poli Alessandro A Ramazzotti Giulia G Matteucci Alessandro A Manzoli Lucia L Lonetti Annalisa A Suh Pann-Ghill PG McCubrey James A JA Cocco Lucio L
Oncotarget 20141101 22
Through the years, different studies showed the involvement of Protein Kinase C (PKC) in cell cycle control, in particular during G1/S transition. Little is known about their role at G2/M checkpoint. In this study, using K562 human erythroleukemia cell line, we found a novel and specific mechanism through which the conventional isoform PKCα positively affects Cyclin B1 modulating G2/M progression of cell cycle. Since the kinase activity of this PKC isoform was not necessary in this process, we d ...[more]