Ontology highlight
ABSTRACT:
SUBMITTER: Gritti M
PROVIDER: S-EPMC4294381 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Gritti Marta M Würth Roberto R Angelini Marina M Barbieri Federica F Peretti Marta M Pizzi Erika E Pattarozzi Alessandra A Carra Elisa E Sirito Rodolfo R Daga Antonio A Curmi Paul M G PM Mazzanti Michele M Florio Tullio T
Oncotarget 20141101 22
Epidemiological and preclinical studies propose that metformin, a first-line drug for type-2 diabetes, exerts direct antitumor activity. Although several clinical trials are ongoing, the molecular mechanisms of this effect are unknown. Here we show that chloride intracellular channel-1 (CLIC1) is a direct target of metformin in human glioblastoma cells. Metformin exposure induces antiproliferative effects in cancer stem cell-enriched cultures, isolated from three individual WHO grade IV human gl ...[more]